Innovative StartUp Incubator and Research SpinOff


ARCADIA is a young Start-up focused on the technology transfer of the basic research results in different fields.


Arcadia is an incubator devoted to the development of innovative ideas behind the development of new products, processes or companies. Arcadia provides a range of services including: office space and equipment, technical and financial planning, business plan consulting and drafting, market research and sector analysis. Moreover, Arcadia support the development and planning of projects through its skills and networking.
Arcadia also promotes and develops its own technologies aimed at developing sensors for the diagnosis of neurodegenerative diseases based on different detection techniques as fluorescensce, SPR and electrochemistry.



SHORT DESCRIPTION OF THE COMPANY

ARCADIA is a young Start-up focused on the technology transfer of the basic research results in different fields. Arcadia is an incubator devoted to the development of innovative ideas behind the development of new products, processes or companies. Arcadia provides a range of services including: office space and equipment, technical and financial planning, business plan consulting and drafting, market research and sector analysis. Moreover, Arcadia support the development and planning of projects through its skills and networking. Arcadia also promotes and develops its own technologies aimed at developing sensors for the diagnosis of neurodegenerative diseases based on different detection techniques as fluorescensce, SPR and electrochemistry.



MAIN RESEARCH LINES

- Plasmonic sensors for medical diagnostic
- Fluorescent sensors for medical diagnostic
- Electrochemical sensors for medical diagnostic
- Project’ s planning and coordination
- Project’s networking
- Incubation services



INSTRUMENTS AND SERVICES OFFERED

Spotter Microarray Sci Flex Arrayer, Scanner SensoSpot® Microarray Analyzers, Direct-Q® 3, Water Purification system ( MilliQ), Chemical Cabinet,centrifuges. Office (co-working), Staff consulting, Financial advisory, Professional consulting, Meeting room, Project’s coordination and networking.



PROJECTS IN PROGRESS

PASSBAND The aim of the project is the development of a multiparameter sensor based on nanostructured plasmonic surfaces able to identify biomarker related to the development of NS diseases as Multiple sclerosis and Alzheimer’s disease. (Start / End: Oct2017 -July 2018) EXIN: Development of the pre-industrial prototype of an innovative safety system for the identification of very low concentrations of explosives within public infrastructures through the analysis of the air in an environment. Specifically, the final product is designed for use of civil security in the context of critical public and private infrastructures, with particular attention to cases in which objects, bags, clothing are deposited for long or short periods. Examples of applications are: cinemas, shopping centers, post offices, luggage depots, etc. (POR CRO Part FERS 2014-2020, Action 1.1.4. "Support for collaborative R & D activities for the development of new sustainable technologies, new products and services" ID 10052781; Start / End: Aug 2017-Oct 2018)



PASSBAND



The aim of this project is to develop plasmonic biosensors for the detection of protein molecules of interest for the early diagnosis of neurodegenerative diseases such as Alzheimer's disease (MA) and multiple sclerosis (MS). For this purpose, we have defined two strategies for analyzing biological markers in simple and complex systems, simulating the dynamics that occur in vivo. The two strategies are based on the recognition between primary and secondary antibody, a methodology known and used constantly, one based on the recognition of proteins through aptamers produced specifically. Two detection methods were used, the fluorescence, generated by a fluorophore linked to the target molecules and the plasmonic signal of the SPR sensor to be able to compare the data obtained with both techniques. To optimize the plasmonic signal, gold devices have been created with a defined period and functionalized with SAM (self-assembled-monolayer) of MUA and MCH to improve the affinity between the support and the biomolecules. In the course of the project in order to obtain greater reproducibility and to evaluate with precision the potentials of the developed system, a SCIENION S3 spotter was purchased that allowed to dispense pico-drops in order to obtain micro-arrays with a defined deposition scheme and a reduced variability. The possibility of using substrates using the spotter with respect to devices prepared manually, has numerous advantages, linked to the reproducibility of the experiment and the possibility of being able to obtain a large data number using a low amount of material, also associated to a considerable reduction in costs. Regarding the aptamers, the best results were obtained with the fluorescence technique on Slides Life Line, where it was possible to detect the target in different concentrations. As for the SPR biosensor, on the other hand, it was not possible to perform target measurements because the shift recorded between the MUA and the MUA + aptamer complex is not enough to discriminate the two phases on the support. For this reason, a more careful evaluation of the measurement and period conditions of the devices is being study to make the system more sensitive even on very low shifts. As far as the antibody strategy is concerned, the results are better, both in the case of fluorescence, by which it was possible to recognize the antibody in simple and complex systems and in different concentrations, and in the case of the SPR biosensor. The size of the antibody molecule is greater than that of the aptamer, this has allowed us to recognize the immobilized antibody on gold devices and to distinguish the different concentrations.



EXIN



The activities carried out in the Exin project have allowed the implementation of the number of molecules detected at the same time through a redesign of the sensor and of the optical analysis instrumentation according to a multi-parametric approach. The design and development of the suction head: In accordance with the data related to the strategies adapted by the airlines regarding luggage size and sensor specifications, the components of the air system have been designed and integrated into a single prototype with discrete components. The individually developed components were then assembled into a functional prototype and first tested in an ideal environment. This activity took place through the setting up of a laboratory suitable for this type of experimentation where it was possible to have an adequate work space available that allowed the necessary tests to be carried out to define the performance of the probes developed for each target. In this way it was possible to analyze the performances of the capture probes in the presence of different experimental conditions, including the presence of different concentrations of analyte and different measurement conditions. In accordance with the results obtained, the analysis protocols for each substance were drawn up and the optimal analysis conditions were identified. The individual components developed in the project (air collection-treatment system, measuring cell, optical measurement system and sensor) were integrated into a final prototype, which was placed at SAVE-Marco Polo Airport in Venice. Here, more measurement campaigns were carried out on both parts of luggage and entire luggage in order to verify the performance of the finished prototype under actual use conditions.

Main research lines


Plasmonic sensors for medical diagnostic.


Fluorescent sensors for medical diagnostic.


Electrochemical sensors for medical diagnostic.


Project’ s planning and coordination.


Project’s networking.


Incubation services.

Equipment and services


Spotter Microarray Sci Flex Arrayer.


Scanner SensoSpot® Microarray Analyzers.


Direct-Q® 3


Water Purification system (MilliQ).


Chemical Cabinet, centrifuges.


Office (co-working), Staff consulting, Financial advisory, Professional consulting, Meeting room, Project’s coordination and networking.


Ongoing project

Passband

Arcadia | Research 2 Business

The aim of the project is the development of a multiparameter sensor based on nanostructured plasmonic surfaces able to identify biomarker related to the development of NS diseases as Multiple sclerosis and Alzheimer’s disease. (Start / End: Oct2017 -July 2018).


Exin

Arcadia | Research 2 Business

Development of the pre-industrial prototype of an innovative safety system for the identification of very low concentrations of explosives within public infrastructures through the analysis of the air in an environment. Specifically, the final product is designed for use of civil security in the context of critical public and private infrastructures, with particular attention to cases in which objects, bags, clothing are deposited for long or short periods. Examples of applications are: cinemas, shopping centers, post offices, luggage depots, etc. (POR CRO Part FERS 2014-2020, Action 1.1.4. "Support for collaborative R & D activities for the development of new sustainable technologies, new products and services" ID 10052781; Start / End: Aug 2017-Oct 2018).


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